L-Iron lactate
ferrous lactate
CAS: 5905-52-2
Molecular Formula: C6H10FeO6
L-Iron lactate - Names and Identifiers
| Name | ferrous lactate |
| Synonyms | HSDB 462 L-Iron lactate iron dilactate Ferrus Lactate FERROUS LACTATE ferrous lactate iron(2+)lactate UNII-5JU4C2L5A0 ironlactate[qr] Iron(2+) lactate Iron(II) lactate IRON (II) LACTATE L-Ferrous lactate iron(2)lactate[qr] Iron(II) lactate hydrate IRON(II)-L-2-HYDROXY-PROPIONATE iron(2+) bis(2-hydroxypropanoate) |
| CAS | 5905-52-2 |
| EINECS | 227-608-0 |
| InChI | InChI=1/2C3H6O3.Fe/c2*1-2(4)3(5)6;/h2*2,4H,1H3,(H,5,6) |
L-Iron lactate - Physico-chemical Properties
| Molecular Formula | C6H10FeO6 |
| Molar Mass | 233.99 |
| Boling Point | 227.6°C at 760 mmHg |
| Flash Point | 109.9°C |
| Vapor Presure | 0.015mmHg at 25°C |
| Merck | 13,4084 |
| BRN | 6099658 |
| Storage Condition | Room Temprature |
| Physical and Chemical Properties | Greenish white crystalline powder or crystal. Slightly abnormal odor, slightly sweet metallic taste. This product is damp or its aqueous solution after oxidation into a yellow brown iron salt containing. Light can promote oxidation. Iron ions react with other food additives and are easily colored. Soluble in water, into a green transparent liquid, acidic. Practically insoluble in ethanol. |
| Use | Widely used in food, beverage, dairy products, salt, nutrient solution, medicine, etc |
L-Iron lactate - Risk and Safety
| WGK Germany | 2 |
| RTECS | OD5525000 |
| Toxicity | LD50 orally in mice: 147 ±30 mg/kg (Eickholt, White) |
L-Iron lactate - Nature
Open Data Verified Data
A slightly greenish to yellow crystalline or crystalline powder with a slightly sweet metallic taste. Soluble in water, difficult to dissolve in ethanol. The aqueous solution is a green transparent solution, which is weakly acidic. It is easily oxidized in light, heat and air and decomposes at high temperature.
Last Update：2024-01-02 23:10:35
L-Iron lactate - Preparation Method
Open Data Verified Data
prepared from calcium lactate solution plus ferrous sulfate or ferric chloride solution. Alternatively, the reaction of sucrose and refined iron powder is added to the lactic acid solution, and then the iron lactate is obtained by recrystallization.
Last Update：2022-01-01 10:09:40
L-Iron lactate - Use
Open Data Verified Data
ferrous lactate is a good food Iron fortifier, the absorption effect is better than that of inorganic iron. China's regulations (all on the basis of Iron), for the amount of 600 ~ 1200mg/kg; Can also be used for dairy products and infant food, the amount of 24 ~ 48mg/kg; Can also be used for beverages, the dosage is 10~20mg/kg.
Last Update：2022-01-01 10:09:40
L-Iron lactate - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| pharmacological effects | ferrous lactate is mainly used for the treatment of ischemic anemia, iron is an indispensable element in the body, is an important component of hemoglobin myoglobin and a variety of tissue enzymes. Iron deficiency can cause iron deficiency anemia or various other iron deficiency disorders. High absorption rate of ferrous lactate, can be used as iron supplements. The main side effects of ferrous lactate is obvious gastrointestinal reaction, after taking can appear Nausea, Vomit, stomach discomfort symptoms, may cause constipation, Melena and other clinical manifestations. In the treatment of anemia in oral iron disease should pay attention to diet, eat more nutrition easily digestible food, eat more dry fruit food, patients do not smoke alcohol, should be reasonable diet, pay attention to rest. |
| content analysis | , note that, without splash of the solution, it was evaporated to dryness and burned to complete Ash (about 3H) at 550-600 °c. Add 10ml hydrochloric acid, boil to almost white insoluble matter, add water to 30ml, filter, wash insoluble matter with water, wash and filtrate, then add water to 100ml, draw 25ml into the iodine bottle, add 4g of potassium iodide, place in the dark for 15min, add 0.1 ml of water, and titrate with mol/L sodium thiosulfate solution, drop to light yellow, add 1% starch solution (1 ml) and continue titration to the end point (light yellow just disappeared). At the same time do blank test. Total iron content (%) = c(V2-V1)× 10 × 0.005585/(W × 25/100) × 100 where V1 -- the m1 number of 0.1mol/L sodium thiosulfate consumed in the titration blank; V2 -- the ml number of 0.1mol/L sodium thiosulfate consumed in the titration sample; c -- the concentration of sodium thiosulfate solution, mol/L;W-sample weight, g;0.005585-0.1mol/L sodium thiosulfate 1ml equivalent to the weight of iron, g. Add TS-89 ml of water and 5ml of phosphoric acid to the Erlenmeyer flask, shake well, add 5ml of concentrated sulfuric acid, shake well, and add 2-3 drops of diphenylamine test solution (), titrate with 0.1mol/L potassium permanganate standard solution to light red for 30s. Ferrous iron content (%) = V × c × 10 × 0.005585/W × 100 where V -- ml of potassium permanganate solution consumed during titration; c -- concentration of potassium permanganate standard solution, mol/L;W-sample volume, g;0.005585-0.1mol/L potassium permanganate solution 1ml equivalent to the weight of ferrous iron, g. Accurately weigh about 2g of the pre-dried sample, move it into a 100ml volumetric flask, mix it with water. 20ml of the sample solution was aspirated and placed in a 100ml Erlenmeyer flask. Add 5ml of 85%(V/V) formic acid. Titrate with 0.1mol/L potassium permanganate to pink. Each mI0.1mol/L of potassium permanganate corresponds to c6h10feo623.40 mg.|
| toxicity | LD50 4.875g/kg (mouse, oral), or 3.73g/kg (rat, oral). GRAS (FDA,§ 73.165, § 182.5311,§ 184.1311,2000).ADI 0.8mg/kg(FAO/WHO,2001). |
| usage limit | FAO/WHO(1990): as an iron source, the total iron content is 0.8mg/kg body weight. GB 14880-94: same as "01215, ferrous sulfate". GB 2760-2000: soybean milk powder, soybean powder, 200 ~ 500mg/kg. |
| Use | nutritional supplement (iron fortifier). The daily requirement is 16mg for adults and 6mg for infants (Japanese standard). The addition amount of the iron agent for fortifying the milk powder is about 6mg/100g. For wheat flour, biscuits, bread when the use of 2~3mg/100g. Rats on the product of fortified soy milk, the absorption rate (of iron) is very strong. Color modifier. It is widely used in food, beverage, dairy products, salt, nutrient solution, medicine, etc. Ferrous lactate is a good food Iron fortifier with better absorption effect than inorganic iron. China's provisions can be used for the inclusion of sugar, the use of 600 ~ 1200mg/kg (iron, the same below); Can also be used for dairy products and infant food, the use of 60 ~ 100mg/kg; can also be used for cereals and their products, the use of 24~48mg/kg; Can also be used for beverages, the use of 10~20mg/kg. ferrous lactate is a food and feed additive and a drug for the treatment of anemia. The daily requirement is 16mg for adults and 6mg for infants. As an iron fortifier, In the United States, the dosage of flour is 3mg/100g, the dosage of bread is 2mg/100g, and the milk powder is 6mg/100g. Iron compounds are unstable to light, and iron ions can react with antioxidants to stain, and care should be taken when using them. |
| production method | prepared from calcium lactate solution plus ferrous sulfate or ferric chloride solution, it is also possible to add sucrose to the lactic acid solution and react with the refined iron powder, and then crystallize to obtain ferrous lactate. The product can be prepared by reacting calcium lactate or sodium lactate with ferrous sulfate (the mass ratio of solvent water amount to ferrous sulfate is 2:1) at 45~50 ℃ and pH 2.5~3.0 for 40min. obtained by the reaction of calcium lactate or sodium lactate solution with ferrous sulfate or ferrous chloride. Lactic acid solution to add sucrose and refined iron powder, direct reaction after crystallization. In order to prevent oxidation, the reaction should be concentrated, crystallization, drying, closed storage. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-10 22:29:15
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